{"id":1831,"date":"2022-03-18T11:21:00","date_gmt":"2022-03-18T09:21:00","guid":{"rendered":"https:\/\/pediatria-spisanie.eu\/2022\/03\/18\/nov-termodinamichen-metod-za-registracia-i-analiz-na-promenite-v-cerebrospinalnata-technost\/"},"modified":"2025-05-21T21:50:13","modified_gmt":"2025-05-21T18:50:13","slug":"nov-termodinamichen-metod-za-registracia-i-analiz-na-promenite-v-cerebrospinalnata-technost","status":"publish","type":"post","link":"https:\/\/pediatria-spisanie.eu\/en\/2022\/03\/18\/nov-termodinamichen-metod-za-registracia-i-analiz-na-promenite-v-cerebrospinalnata-technost\/","title":{"rendered":"A new \u0422hermodynamic \u041cethod for Registration and Analysis of Changes in Cerebrospinal Fluid in a Child with Acute Lymphoblastic Leukemia -Clinical Observation"},"content":{"rendered":"\n\n\t\t
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K. Bachvarov, B. Antonova, S. Abarova, D. Konstantinov, B. Tenchov <\/h3>\n

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Abstract<\/h2>\n\n\n\n

This clinical observation concerns the application of differential scanning calorimetry (DSC) used in a child with meningeal relapse of acute lymphoblastic leukemia. A specific high-intensity endothermic peak was found in the CSF thermogram, which gradually attenuated as the neoplastic pleocytosis decreased and disappeared. It continued to be observed for a period of time after cells in the CSF were no longer demonstrable. DSC of the cerebrospinal fluid proteome is a useful and affordable method for the diagnosis and follow-up of patients with diseases involving the cerebrospinal fluid. The method has not yet been validated as a routine test, but has the potential to be used in the future as a complementary diagnostic approach. <\/p>\n\n\n\n

Keywords:<\/strong> differential scanning calorimetry (DSC), acute lymphoblastic leukemia, meningeal relapse, CSF neoplastic pleocytosis, CSF proteome<\/p>\n\n\n

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Bibliography<\/strong><\/h2>\n\n\n\n
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    Address for correspondence:<\/strong><\/p>\n\n\n\n

    Department of pediatric hematology and oncology,
    University Hospital \u201cQueen Joanna\u201d
    8, \u201cByalo more\u201d, Str.
    1527, Sofia
    Bulgaria
    e-mail:     k.batschvarov@abv.bg<\/a><\/p>\n\n\n\n

    \u00a0<\/p>\n\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

    K. Bachvarov, B. Antonova, S. Abarova, D. Konstantinov, B. Tenchov<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_pediatria_doi":"","footnotes":""},"categories":[1301,1331],"tags":[2384,2385,1734,1688,2386],"class_list":["post-1831","post","type-post","status-publish","format-standard","hentry","category-articles","category-issue-1-2022","tag-b-antonova-en","tag-b-tenchov-en","tag-d-konstantinov-en","tag-k-bachvarov-en","tag-s-abarova-en"],"_links":{"self":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts\/1831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/comments?post=1831"}],"version-history":[{"count":1,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts\/1831\/revisions"}],"predecessor-version":[{"id":1833,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts\/1831\/revisions\/1833"}],"wp:attachment":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/media?parent=1831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/categories?post=1831"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/tags?post=1831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}