{"id":1781,"date":"2022-06-18T14:00:00","date_gmt":"2022-06-18T11:00:00","guid":{"rendered":"https:\/\/pediatria-spisanie.eu\/2022\/06\/18\/hronochen-hepatit-b-lechenie-na-maikata\/"},"modified":"2025-05-21T16:53:12","modified_gmt":"2025-05-21T13:53:12","slug":"hronochen-hepatit-b-lechenie-na-maikata","status":"publish","type":"post","link":"https:\/\/pediatria-spisanie.eu\/en\/2022\/06\/18\/hronochen-hepatit-b-lechenie-na-maikata\/","title":{"rendered":"Chronic hepatitis B &#8211; Treatment of the Mother, Prevention of the Newborn"},"content":{"rendered":"\n\n\t\t<div class=\"icon-box featured-box icon-box-left text-left is-small\"  >\n\t\t\t\t\t<div class=\"icon-box-img\" style=\"width: 20px\">\n\t\t\t\t<div class=\"icon\">\n\t\t\t\t\t<div class=\"icon-inner\" >\n\t\t\t\t\t\t<img decoding=\"async\" width=\"48\" height=\"48\" src=\"https:\/\/pediatria-spisanie.eu\/wp-content\/uploads\/2024\/12\/icons8-user-48.png\" class=\"attachment-medium size-medium\" alt=\"\" \/>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t<div class=\"icon-box-text last-reset\">\n\t\t\t\t\t\t\t\t\t\n<h3>R. Komitova, A. Kevorkyan, M. Atanasova, E. Golkocheva-Markova <\/h3>\n<p> <\/br>\n<\/p>\n\t\t<\/div>\n\t<\/div>\n\t\n\t\n<div class=\"is-divider divider clearfix\" ><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u0410bstract<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The mother-to-child transmission of hepatitis B virus (HVB), frequent in endemic countries, accounts for about 40-50% of chronic HBV infections worldwide. Therefore, blocking the transmission is a significant step toward eliminating hepatitis B. The study presented a case of a successfully prophylactic baby girl born to a mother with chronic HBV infection diagnosed during pregnancy. She was prescribed antiviral therapy in the last trimester. The child was followed-up by the authors, proving her protection against HBV. In addition, we collected epidemiological data from family household contacts. The results&nbsp; revealed&nbsp; the source of the infection &#8211;&nbsp; the grandmother of the baby with chronic HBV infection.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>\u041a\u0435y words:<\/em><\/strong>&nbsp; hepatitis B virus, perinatal transmission, antiviral prophylaxis, hepatitis B vaccine, hepatitis B immunoglobulin<\/p>\n\n\n<div class=\"is-divider divider clearfix\" ><\/div>\n\n\n\t\t<div class=\"wp-block-woocommerce-memberships-member-content\">\n\t\t\t\t\t<div class=\"woocommerce\">\n\t\t\t<div class=\"woocommerce-info wc-memberships-restriction-message wc-memberships-message wc-memberships-content-restricted-message\">\n\t\t\t\tTo access this content, you must purchase <span class=\"wc-memberships-products-grant-access\"><a href=\"https:\/\/pediatria-spisanie.eu\/en\/produkt\/godishen-abonament\/\">\u0413\u043e\u0434\u0438\u0448\u0435\u043d \u0430\u0431\u043e\u043d\u0430\u043c\u0435\u043d\u0442<\/a><\/span>.\t\t    <\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\n\n<h2 class=\"wp-block-heading\"><strong>Bibliography<\/strong><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>WHO. Prevention of mother-to-child transmission of hepatitis B virus: guidelines on antiviral prophylaxis in pregnancy. World Health Organization,&nbsp;Geneva July 27, 2020 <a href=\"https:\/\/www.who.int\/publications\/i\/item\/978-92-4-000270-8\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.who.int\/publications\/i\/item\/978-92-4-000270-8<\/a><\/li>\n\n\n\n<li>Hou J, Wang G, Wang F, et al. Chinese Society of Hepatology; Chinese medical association Chinese society of infectious diseases; Chinese medical association. guideline of prevention and treatment for chronic hepatitis B (2015 Update) J Clin Transl Hepatol. 2017;5:297\u2013318<\/li>\n\n\n\n<li>McMahon BJ, Alward WL, Hall DB, et al. Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state. J Infect Dis. 1985 Apr;151(4):599-603<\/li>\n\n\n\n<li>Wei KP, Zhu FC, Liu JX, et al. The efficacy of two different dosages of hepatitis B immunoglobulin combined with hepatitis B vaccine in preventing mother-to-child transmission of hepatitis B virus: A prospective cohort study. Vaccine. 2018 Jan 4;36(2):256-263.<\/li>\n\n\n\n<li>National Institute for Health and Care Excellence. Hepatitis B (chronic): diagnosis and management. Clinical guidelines [CG165]. In: National institute for health and care excellence. Available from: https:\/\/www.nice.org.uk\/guidance\/cg165 .<\/li>\n\n\n\n<li>Iliev B., B. Stambolov, E. Marinova et al. The prevalence of the HBsAg carrier state among pregnant women and its effect on newborn infants. Our experience in using hepatitis B vaccine and hepatitis B immunoglobulin to immunize infants born to mothers who carry HBsAg. Akush Ginekol.1989; 28(6): 37-42<\/li>\n\n\n\n<li>Veronese P, Dodi I, Esposito S, et al . Prevention of vertical transmission of hepatitis B virus infection. World J Gastroenterol. 2021 Jul 14;27(26):4182-4193.<\/li>\n\n\n\n<li>Wang FS, Fan JG, Zhang Z, et al. The global burden of liver disease: The major impact of China.&nbsp;Hepatology. 2014;60:2099-2108.<\/li>\n\n\n\n<li>Lin X, Guo Y, Zhou A, et al. Immunoprophylaxis failure against vertical transmission of hepatitis \u0412 virus in the Chinese population: A hospital-based study and a meta-analysis. Pediatr Infect Dis J. 2014;33:897\u2013903<\/li>\n\n\n\n<li>Wen WH, Chang MH, Zhao LL, et al. Mother-to-infant transmission of hepatitis B virus infection: significance of maternal viral load and strategies for intervention. J Hepatol. 2013;59:24\u201330.<\/li>\n\n\n\n<li>Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010.&nbsp;<em>Lancet<\/em>. 2012;380:2095-2128<\/li>\n\n\n\n<li>WHO. Hepatitis B <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-\">https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-<\/a><\/li>\n\n\n\n<li>Funk AL, Lu Y, Yoshida K, et al. Efficacy and safety of antiviral prophylaxis during pregnancy to prevent mother-to-child transmission of hepatitis B virus: a systematic review and meta-analysis. Lancet Infect Dis. 2021 Jan;21(1):70-84.<\/li>\n\n\n\n<li>Lee C, Gong Y, Brok J, et al. Effect of hepatitis B immunization in newborn infants of mothers positive for hepatitis B surface antigen: systematic review and meta-analysis.&nbsp;BMJ.&nbsp;2006;332:328\u2013336.<\/li>\n\n\n\n<li>Sarin SK, Kumar M, Lau GK, et al.&nbsp; Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update. Hepatol Int. 2016;10:1\u201398<\/li>\n\n\n\n<li>Schillie S, Murphy TV, Fenlon N, et al. Update: Shortened interval for postvaccination serologic testing of infants born to hepatitis \u0412-infected mothers.&nbsp;MMWR Morb Mortal Wkly Rep.&nbsp;2015;64:1118\u2013112<\/li>\n\n\n\n<li>Terrault NA, Lok ASF, McMahon BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018 Apr;67(4):1560-1599<\/li>\n\n\n\n<li>Goldstein S, Zhou F, Hadler SC,&nbsp; et al. A mathematical model to estimate global hepatitis B disease burden and vaccination impact.&nbsp;Int J Epidemiol. 2005;34:1329-1339.<\/li>\n\n\n\n<li>European Association for the Study of the Liver ; European Association for the Study of the Liver. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection.&nbsp;J Hepatol.&nbsp;2017;67:370\u2013398.&nbsp;<\/li>\n\n\n\n<li>Schillie S, Vellozzi C, Reingold A, et al. Prevention of hepatitis \u0412 virus infection in the United States: recommendations of the advisory committee on immunization practices.&nbsp;MMWR Recomm Rep.&nbsp;2018;67:1\u20133<\/li>\n\n\n\n<li>Sirilert S, Tongsong T. Hepatitis b virus infection in pregnancy: An update on evidence-based management. Obstet Gynecol Surv. 2020 Sep;75(9):557-565.<\/li>\n<\/ol>\n\n\n<div class=\"is-divider divider clearfix\" ><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Address for correspondence:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Department of Infectious diseases,<br>Parasitology and Tropical medicine, Faculty of Medicine,<br>Medical University<br>15A, Vassil Aprilov, Blvd.<br>4000, Plovdiv, Bulgaria<br>e-mail: <a href=\"mailto:radka.komitova@yahoo.com\">radka.komitova@yahoo.com<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>R. Komitova, A. Kevorkyan, M. Atanasova, E. Golkocheva-Markova<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_pediatria_doi":"","footnotes":""},"categories":[1301,1334],"tags":[2254,2255,2256,2257,2258,2259,2260,2261,2262,2263,2264,2265,2266,2267,2268],"class_list":["post-1781","post","type-post","status-publish","format-standard","hentry","category-articles","category-issue-2-2022","tag-antiviral-prophylaxis-en","tag-hepatitis-b-vaccine-en","tag-hepatitis-b-virus-en","tag-perinatal-transmission-en","tag-xronichen-hepatit-b-lechenie-na-majkata-en","tag-a-kevorkyan-en","tag-antivirusna-profilaktika-en","tag-virus-na-hepatit-v-en","tag-e-golkocheva-markova-en","tag-m-atanasova-en","tag-perinatalna-transmisiya-en","tag-prevencziya-na-novorodenoto-en","tag-r-komitova-en","tag-hepatit-v-vaksina-en","tag-hepatit-v-imunoglobulin-en"],"_links":{"self":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts\/1781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/comments?post=1781"}],"version-history":[{"count":1,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts\/1781\/revisions"}],"predecessor-version":[{"id":1783,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts\/1781\/revisions\/1783"}],"wp:attachment":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/media?parent=1781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/categories?post=1781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/tags?post=1781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}