{"id":1642,"date":"2024-03-18T16:12:00","date_gmt":"2024-03-18T14:12:00","guid":{"rendered":"https:\/\/pediatria-spisanie.eu\/2024\/03\/18\/chestota-na-ostrovni-antitela-i-diabetna-ketoacidoza\/"},"modified":"2025-05-20T14:40:32","modified_gmt":"2025-05-20T11:40:32","slug":"chestota-na-ostrovni-antitela-i-diabetna-ketoacidoza","status":"publish","type":"post","link":"https:\/\/pediatria-spisanie.eu\/en\/2024\/03\/18\/chestota-na-ostrovni-antitela-i-diabetna-ketoacidoza\/","title":{"rendered":"Prevalence of islet autoantibodies and diabetic ketoacidosis among children and adolescents with newly diagnosed diabetes mellitus at one Diabetes Center (2019 \u2013 2023)"},"content":{"rendered":"\n\n\t\t
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Yuliya Bazdarska, Hari Stefanov, Yana Bocheva, Gergana Chausheva, Violeta Iotova <\/h3>\n

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Abstract<\/h2>\n\n\n\n

Background: <\/em><\/strong>Worldwide, the most frequentinitial presentation of type 1 diabetes (T1D) is still the diabetic ketoacidosis. Being an autoimmune diseases, T1D most frequently associates with islet autoantibodies (Abs). <\/p>\n\n\n\n

Aim:<\/em><\/strong> <\/em>To evaluate the frequency of positive diabetes-associated islet autoantibodies and the prevalence of DKA at T1D diabetes onset in youth at Varna\u2019s diabetes center for a period of four years (2019 – 2023). <\/p>\n\n\n\n

Methods:<\/em><\/strong> All 160 consecutive newly-diagnosed patients were enrolled in the study. Demographic and laboratory data was collected. Participants were tested for anti-GAD65, anti-IA2 and anti-IAA by ELISA. <\/p>\n\n\n\n

Results:<\/em><\/strong> The mean age of the participants was 9.0\u00b14.3 years (57% boys). Of total, 44.3% were with initial DKA, and 16.9% were with severe DKA. Weak significant correlations were found between the level of DKA and age (r=-0.143, p<0.03), HbA1c (r=0.26, p=0.001) as well as C-peptide levels (r=-0.204, p=0.012). Of total, 81.6% were with at least one positive diabetes related autoantibody – 34% had 1 positive Ab, \u00a041.5% had 2 Abs\u00a0 and 6.1% of patients were with 3 positive Abs. The most frequent Ab was anti-GAD65 (69.4%) followed by anti-IA2 (51%), and anti-IAA (15.6%), p<0.01. Weak significant correlations were found between positivity of anti-GAD65 and anti-IAA (r=0.310, <0.0001). N correlation was found between the presence and number of positive autoantibodies and the DKA severity. <\/p>\n\n\n\n

Conclusion: <\/em><\/strong>Initial DKA continues to be very frequent at T1D presentation in youth especially at younger age, higher BGL and lower C-peptide. The high prevalence of positive diabetic autoantibodies at diagnosis is a compelling proof for their routine testing in preclinical stages of T1D and screening in siblings to prevent diabetic ketoacidosis.<\/p>\n\n\n\n

Keywords: <\/strong>diabetic ketoacidosis, initial DKA, type 1 diabetes mellitus, antibodies, anti-GAD, anti-IA2, anti-IAA<\/p>\n\n\n

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    <\/div>\n\n\n\n

    Address for correspondence:<\/strong><\/p>\n\n\n\n

    First Pediatric clinic with PICU;
    University Hospital \u201cSveta Marina\u201d, Varna
    1, \u201cHr. Smirnenski\u201d, Blvd. floor 5
    9010, Varna
    Bulgaria
    Email:     yuliya.bazdarska@gmail.com<\/a>\u00a0\u00a0\u00a0\u00a0\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

    Yuliya Bazdarska, Hari Stefanov, Yana Bocheva, Gergana Chausheva, Violeta Iotova<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_pediatria_doi":"","footnotes":""},"categories":[1301,1333],"tags":[],"class_list":["post-1642","post","type-post","status-publish","format-standard","hentry","category-articles","category-issue-1-2024"],"_links":{"self":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts\/1642","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/comments?post=1642"}],"version-history":[{"count":2,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts\/1642\/revisions"}],"predecessor-version":[{"id":1648,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts\/1642\/revisions\/1648"}],"wp:attachment":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/media?parent=1642"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/categories?post=1642"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/tags?post=1642"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}