{"id":1613,"date":"2023-12-19T11:37:00","date_gmt":"2023-12-19T09:37:00","guid":{"rendered":"https:\/\/pediatria-spisanie.eu\/2023\/12\/19\/inovativni-markrei-na-vuzpalenie-pri-deca-sys-septichni\/"},"modified":"2025-05-18T23:46:11","modified_gmt":"2025-05-18T20:46:11","slug":"inovativni-markrei-na-vuzpalenie-pri-deca-sys-septichni","status":"publish","type":"post","link":"https:\/\/pediatria-spisanie.eu\/en\/2023\/12\/19\/inovativni-markrei-na-vuzpalenie-pri-deca-sys-septichni\/","title":{"rendered":"Innovative Inflammatory Markers in Septic and Critically ill Children"},"content":{"rendered":"\n\n\t\t
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A. Hadzhieva-Hristova, T. Stoeva, V. Iotova <\/h3>\n

<\/br>\n<\/p>\n\t\t<\/div>\n\t<\/div>\n\t\n\t\n

<\/div>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Critical septic conditions caused by infectious pathogens are one of the leading causes of death in
children globally.\u00a0The lack of introduced algorithms for rapid assessment of the condition of these
patients, the use of\u00a0inflammatory markers with low specificity and sensitivity and the use of standard
microbiological methods pose a risk of delaying the diagnosis and treatment in children with infectious
complications. The aim of this scientific review is to create and test a convenient algorithm for early
assessment, diagnosis and treatment of septic conditions in children.\u00a0 It will be assessed the
physiological condition of patients using pSOFA, PRISM III and IV scores and the risk of mortality will be
calculated also. The routine biochemical parameters of inflammation, procalcitonin will be compared with
the new ones.\u00a0Innovative markers of inflammation will be studied – Presepsin, soluble mannose receptor
(sMR)\u00a0by ELISA method for research purposes.
An innovative and rapid method with high sensitivity and specificity (MALDI-TOF-MS) for the species
identification of the pathogens will be performed, based on microbial protein analysis, incl. direct
identification of the causative agent in the blood sample\u00a0within 1- 2 hours. As a result, it is expected: to
create a comprehensive assessment of critical and septic conditions in children by using innovative scores
for the first time in Bulgaria;\u00a0to find a correlation between the effectiveness of new inflammatory laboratory markers with the old ones and to choose the most appropriate combination of markers for an early detection of inflammation in the course of sepsis development in children;\u00a0to improve the diagnostic process of microbial identification by using an innovative method for early detection of the infectious pathogen associated with the septic condition. More importantly, it will help the prevention, prognosis and will improve the therapeutic approach in children with septic and critical conditions.\u00a0\u00a0\u00a0\u00a0
Key words:<\/strong> sepsis, children, MALDI-TOF-MS, procalcitonin, s\u041cR, presepsin<\/p>\n\n\n

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  33. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/sepsis <\/li>\n<\/ol>\n\n\n
    <\/div>\n\n\n\n

    Address for correspondence:<\/strong><\/p>\n\n\n\n

    <\/p>\n\n\n\n

    First children’s clinic with a children’s department
    for intensive treatment
    UMHAT \u201cSveta Marina\u201d – Varna
    1, \u201cHristo Smirnenski\u201d, Str.
    9010, Varna, Bulgaria
    e-mail:     hadzhieva.adriana@gmail.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    A. Hadzhieva-Hristova, T. Stoeva, V. Iotova<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_pediatria_doi":"","footnotes":""},"categories":[1301,1341],"tags":[1825,1826,1827,1828,1829,1489,1445,1830,1831,1832],"class_list":["post-1613","post","type-post","status-publish","format-standard","hentry","category-articles","category-issue-4-2023","tag-maldi-tof-ms-en","tag-presepsin-en","tag-procalcitonin-en","tag-smr-en","tag-a-hadzhieva-hristova-en","tag-v-jotova-en","tag-decza-en","tag-inovativni-markeri-na-vazpalenie-pri-decza-sas-septichni-i-kritichni-sastoyaniya-en","tag-sepsis-en","tag-t-stoeva-en"],"_links":{"self":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts\/1613","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/comments?post=1613"}],"version-history":[{"count":1,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts\/1613\/revisions"}],"predecessor-version":[{"id":1615,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/posts\/1613\/revisions\/1615"}],"wp:attachment":[{"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/media?parent=1613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/categories?post=1613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pediatria-spisanie.eu\/en\/wp-json\/wp\/v2\/tags?post=1613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}